All Slay the Spire 2 Debuff and how they work

Slay the Spire 2 is not without its debuffs, and if you want to know how they work, we’ve got you covered.

Negative effects are applied by debuffs in STS 2, and they can be applied to you or your enemy. In the game, there are multiple debuffs, and even though the game provides in-game descriptions when hovering over the icon, some debuffs can still be confusing.

So, if you’re curious about how they work, here’s the best STS 2 debuff guide for you!

Slay the Spire 2 Debuffs explained

There are 32 debuffs in Slay the Spire 2, such as Vulnerable, Weak, Frail, Confused, Crush Under, Dark Shackles, Demise, Hang and more.. Many of which forces both enemies and the player character with 50% or more damage inflicted. Double damage, negative block and even lost dexterity..

Here’s what they do.

List Of STS 2 Debuff Cards And Abilities

Debuff	Effect
Vulnerable	Affected players or enemies receive 50% more damage from attacks.
Weak	Affected players or enemies’ attacks deal 25% less damage
Frail	Affected players or enemies gain 25% less block from cards (relics, and potions are excluded)
Biased Cognition (Defect)	Defect loses X Focus at the start of his turn
Confused	Costs of cards are randomized from 0 to 3. This debuff comes from the Snecko Eye relic.
Conqueror (Regent)	Sovereign Blade deals double damage
Crush Under	Affected enemies lose X strength
Dark Shackles	Affected enemies lose X strength
Debilitate	Makes Vulnerable and Weak twice as effective.
Demise	Enemies affected lose X HP at the end of turn. Currently, Powdered Demise is the only source of this debuff, and this makes an enemy lose 9 HP per turn.
Doom (Necrobinder)	At the end of the turn, players or enemies with HP equal to or lower than Doom will die.
Dying Star (Regent)	Affected enemies lose X strength
Enfeebling Touch (Necrobinder)	Affected enemies lose X strength
Flanking (Silent)	A multiplayer-exclusive debuff that makes enemies deal X times more damage to an enemy
Frail	Affected players gain 25% less block from cards
Grapple (Ironclad)	Whenever you gain block this turn, deal X damage to afflicted enemy
Hang	All Hang cards deal X times more damage
Knockdown	Multiplayer-exclusive debuff that makes enemies receive X times more damage to enemy this turn.
Mangle	Lose X strength until the end of this turn
Monarch’s Gaze Strength down (Regent)	Lose X strength until the end of this turn
Neurosurge (Necrobinder)	A debuff given to the player. At the start of the turn, the player receives 3 doom.
No block	The player cannot gain block from cards for X turns.
No draw	The player cannot gain block from cards for X turns.
Oblivion (Necrobinder)	Enemies receive X doom whenever a player plays a card this turn
Poison (Silent)	At the start of the enemies’ turn, they lose X HP then reduces 1 Poison
Shackling Poison (Silent)	Lose X Strength until the end of turn
Shrink	From Beetle juice potion. Attacks deal 30% damage.
Sic ‘Em (Necrobinder)	Whenever Osty hits an enemy this turn, Summon X
Strangle	Enemies lose X HP whenever you play a card this turn
Tag Team	Multiplayer-exclusive. The next attack another players plays on the enemy is played an extra time.
The Gambit	High-risk high-reward self-debuff. The Gambit card gives players 50 (75 if upgraded) blocks, but if they take unblocked damage this combat, they die.
Wraith Form	Lose X Dexterity at the start of turn